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Contents

  • Modular Tutorials
    • ForceField Tutorials
    • Alchemical Free Energy (AFE) Tutorials
      • Calculating Absolute Binding Free Energies of Tyk2 Inhibitors
      • Building Simulation Boxes for ABFE Calculations (Tyk2)
      • Equilibrating Endstates in ABFE Calculations (Tyk2)
      • Creating Boresch Restraints for ABFE Calculations (Tyk2)
      • Generating and Running Lambda Windows for ABFE Calculations (Tyk2)
      • Analyzing ABFE Calculations (Tyk2)
      • Optimizing Lambda Schedules for Alchemical Free Energy Calculations
    • Free Energy Surface Tutorials
    • Machine Learning Tutorials
    • Miscellaneous Tutorials
  • Workshop Materials
  • Internal guides
  • In Progress Tutorials
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  • Alchemical Free Energy (AFE) Tutorials
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Alchemical Free Energy (AFE) Tutorials

Alchemical Free Energy (AFE) Calculations

  • Calculating Absolute Binding Free Energies of Tyk2 Inhibitors
    • Learning objectives
    • Relevant literature
    • Tutorial
      • Running ABFE Calculations with AmberFlow
  • Building Simulation Boxes for ABFE Calculations (Tyk2)
    • Learning objectives
    • Relevant literature
    • Tutorial
      • Building Simulation Boxes for ABFE Calculations
  • Equilibrating Endstates in ABFE Calculations (Tyk2)
    • Learning objectives
    • Relevant literature
    • Tutorial
      • Setting Up and Running End-State Equilibration
  • Creating Boresch Restraints for ABFE Calculations (Tyk2)
    • Learning objectives
    • Relevant literature
    • Tutorial
      • Determining Boresch Restraints
  • Generating and Running Lambda Windows for ABFE Calculations (Tyk2)
    • Learning objectives
    • Relevant literature
    • Tutorial
      • Setting Up and Running Annihilation Simulations
      • Equilibrating the Lambda Windows
  • Analyzing ABFE Calculations (Tyk2)
    • Learning objectives
    • Relevant literature
    • Tutorial
      • Getting Started
      • Overview of the Outputs from An ABFE calculation
  • Optimizing Lambda Schedules for Alchemical Free Energy Calculations
    • Learning objectives
    • Relevant literature
    • Tutorial
      • Optimizing Lambda Schedules
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